Domain structure of bi-functional selenoprotein P
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چکیده
منابع مشابه
Domain structure of bi-functional selenoprotein P.
Human selenoprotein P (SeP), a selenium-rich plasma glycoprotein, is presumed to contain ten selenocysteine residues; one of which is located at the 40th residue in the N-terminal region and the remaining nine localized in the C-terminal third part. We have shown that SeP not only catalyses the reduction of phosphatidylcholine hydroperoxide by glutathione [Saito, Hayashi, Tanaka, Watanabe, Suzu...
متن کاملConserved features of selenoprotein P cDNA.
26. Berry, M. J., Banu, L., Harney, J. W. and Larsen, P. R. (1993) EMBO J. 12,3315-3322 Said, €3. Cole, J. K. and Nornura, M. (1988) Nucleic Acids Res. 16, 10529-10545 Cerretti, 1). P., Mattheakis, I,. C., Kearney, K. K., Vu, 1,. and Nomura, M. (1988) J. Mol. Biol. 204, 309-325 Rould, M. A,, Perona, J. J. and Steitz, T. A. (1991) Nature (London) 352,2 13-2 18 Bettany, A. J. E., Eisenstein, R. S...
متن کاملNMR structure of the calreticulin P-domain.
The NMR structure of the rat calreticulin P-domain, comprising residues 189-288, CRT(189-288), shows a hairpin fold that involves the entire polypeptide chain, has the two chain ends in close spatial proximity, and does not fold back on itself. This globally extended structure is stabilized by three antiparallel beta-sheets, with the beta-strands comprising the residues 189-192 and 276-279, 206...
متن کاملDirect Interaction between Selenoprotein P and Tubulin
Selenium (Se), an essential trace element for human health, mainly exerts its biological function via selenoproteins. Among the 25 selenoproteins identified in human, selenoprotein P (SelP) is the only one that contains multiple selenocysteines (Sec) in the sequence, and has been suggested to function as a Se transporter. Upon feeding a selenium-deficient diet, mice lacking SelP develop severe ...
متن کاملSEPP 1 ( selenoprotein P , plasma , 1 )
Note SEPP1 belongs to selenoproteins, all of which contain selenium in the form of selenocysteine (SeC) and are being synthesized in the presence of UGA codon, specific stem loop structure in 3' UTR of mRNA called SECIS (Selenocysteine Insertion Sequence) and other specific factors. Selenoprotein P is a glycoprotein present mainly in plasma, where it accounts for 40 65% of total selenium in thi...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2004
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20040328